Michael Bakker · Bioinformatics & Pharmaceuticals

Understanding proteins
in motion.

I explore new possibilities for drug discovery by modeling disordered proteins, orphan nuclear receptors, and peptidomimetics—bringing molecular insight to challenging pharmaceutical questions.

Postdoctoral researcher · Charles University, Czech Republic

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Protein ribbon visualization with highlighted helices and a bound molecule

Pharmaceutical ModelingDisordered ProteinsMachine LearningPeptidomimetics

Research focus

Three unexplored paths.
One concentric goal.
Explore the Unexplored.

My research focuses on less-explored areas of pharmacology: diving into the dark proteome through intrinsically disordered proteins, seeking matches for orphan nuclear receptors, and devising new therapeutic strategies by mimicking protein interactions through peptidomimetics.

Dark Proteome

While much of the ordered protein machinery has been mapped, the Dark Proteome represents a significant challenge for targeted therapeutics.

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Undruggable Receptors

Many proteins represent a complex challenge for scientists, as not even a natural ligand has been found. Complex challenges require elegant solutions.

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Peptidomimetics

While small-molecule ligands are frequently tested in large quantities using HITS, peptidomimetics present a unique solution – hijacking biology itself.

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Michael Bakker · B.Sc., M.Sc., Ph.D.

Let’s connect.

I’m a postdoctoral researcher at Charles University in the Czech Republic, with ongoing collaborations with researchers in Germany, Sweden, and the United States. Interested in bioinformatics, pharmaceutical modeling, or protein dynamics? Get in touch to discuss ideas and potential collaborations.

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Selected work